Artículos de revistas
Human peritoneal mesothelial cell death induced by high-glucose hypertonic solution involves Ca2+ and Na+ ions and oxidative stress with the participation of PKC/NOX2 and PI3K/Akt pathways
Fecha
2017Registro en:
Frontiers in Physiology, Volumen 8, Issue JUN, 2018,
1664042X
10.3389/fphys.2017.00379
Autor
Simon, Felipe
Tapia, Pablo
Armisen, Ricardo
Echeverria, Cesar
Gatica, Sebastian
Vallejos, Alejandro
Pacheco, Alejandro
Sanhueza, Maria E.
Alvo Abodovsky, Miriam
Segovia, Erico
Torres, Rubén
Institución
Resumen
© 2017 Simon, Tapia, Armisen, Echeverria, Gatica, Vallejos, Pacheco, Sanhueza, Alvo, Segovia and Torres. Chronic peritoneal dialysis (PD) therapy is equally efficient as hemodialysis while providing greater patient comfort and mobility. Therefore, PD is the treatment of choice for several types of renal patients. During PD, a high-glucose hyperosmotic (HGH) solution is administered into the peritoneal cavity to generate an osmotic gradient that promotes water and solutes transport from peritoneal blood to the dialysis solution. Unfortunately, PD has been associated with a loss of peritoneal viability and function through the generation of a severe inflammatory state that induces human peritoneal mesothelial cell (HPMC) death. Despite this deleterious effect, the precise molecular mechanism of HPMC death as induced by HGH solutions is far from being understood. Therefore, the aim of this study was to explore the pathways involved in HGH solution-induced HPMC death. HGH-induced HPMC deat