dc.creatorVera, Carolina Andrea
dc.creatorOróstica Arévalo, María Lorena
dc.creatorGabler Neale, Fernando
dc.creatorFerreira, Arturo
dc.creatorSelman,
dc.creatorVega Blanco, María Margarita
dc.creatorRomero Osses, Carmen
dc.date.accessioned2019-03-18T11:56:29Z
dc.date.available2019-03-18T11:56:29Z
dc.date.created2019-03-18T11:56:29Z
dc.date.issued2017
dc.identifierInternational Journal of Oncology, Volumen 50, Issue 4, 2018, Pages 1261-1270
dc.identifier17912423
dc.identifier10196439
dc.identifier10.3892/ijo.2017.3892
dc.identifierhttps://repositorio.uchile.cl/handle/2250/167133
dc.description.abstractOvarian cancer is the seventh most common cancer among women worldwide, causing approximately 120,000 deaths every year. Immunotherapy, designed to boost the body's natural defenses against cancer, appears to be a promising option against ovarian cancer. Calreticulin (CRT) is an endoplasmic reticulum (ER) resident chaperone that, translocated to the cell membrane after ER stress, allows cancer cells to be recognized by the immune system. The nerve growth factor (NGF) is a pro-angiogenic molecule overexpressed in this cancer. In the present study, we aimed to determine weather NGF has an effect in CRT translocation induced by cytotoxic and ER stress. We treated A2780 ovarian cancer cells with NGF, thapsigargin (Tg), an ER stress inducer and mitoxantrone (Mtx), a chemotherapeutic drug; CRT subcellular localization was analyzed by immunofluorescence followed by confocal microscopy. In order to determine NGF effect on Mtx and Tg-induced CRT translocation from the ER to the cell membrane, c
dc.languageen
dc.publisherSpandidos Publications
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
dc.sourceInternational Journal of Oncology
dc.subjectCalreticulin
dc.subjectCalreticulin translocation
dc.subjectEndoplasmic reticulum stress
dc.subjectEpithelial ovarian cancer
dc.subjectNerve growth factor
dc.titleThe nerve growth factor alters calreticulin translocation from the endoplasmic reticulum to the cell surface and its signalling pathway in epithelial ovarian cancer cells
dc.typeArtículos de revistas


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