Artículos de revistas
Aging impairs hippocampal- dependent recognition memory and LTP and prevents the associated RyR up-regulation
Fecha
2017Registro en:
Frontiers in Aging Neuroscience, Volumen 9, Issue APR, 2018,
16634365
10.3389/fnagi.2017.00111
Autor
Arias Cavieres, Alejandra
Adasme, Tatiana
Sánchez, Gina
Muñoz, Pablo
Hidalgo Tapia, María Cecilia
Institución
Resumen
© 2017 Arias-Cavieres, Adasme, Sánchez, Muñoz and Hidalgo.Recognition memory comprises recollection judgment and familiarity, two different processes that engage the hippocampus and the perirhinal cortex, respectively. Previous studies have shown that aged rodents display defective recognition memory and alterations in hippocampal synaptic plasticity. We report here that young rats efficiently performed at short-term (5 min) and long-term (24 h) hippocampus-associated object-location tasks and perirhinal cortex-related novel-object recognition tasks. In contrast, aged rats successfully performed the object-location and the novel-object recognition tasks only at short-term. In addition, aged rats displayed defective long-term potentiation (LTP) and enhanced long-term depression (LTD). Successful long-term performance of object-location but not of novel-object recognition tasks increased the protein levels of ryanodine receptor types-2/3 (RyR2/RyR3) and of IP3R1 in young rat hippocampus.