Artículos de revistas
Role of nerve growth factor (NGF) and miRNAs in epithelial ovarian cancer
Fecha
2017Registro en:
International Journal of Molecular Sciences, Volumen 18, Issue 3, 2018,
14220067
16616596
10.3390/ijms18030507
Autor
Retamales-Ortega, Rocío
Oróstica Arévalo, María Lorena
Vera, Carolina
Cuevas, Paula
Hernández, Andrea
Hurtado, Iván
Vega Blanco, María Margarita
Romero Osses, Carmen
Institución
Resumen
© 2017 by the authors. Licensee MDPI, Basel, Switzerland. Ovarian cancer is the eighth most common cancer in women worldwide, and epithelial ovarian cancer (EOC) represents 90% of cases. Nerve growth factor (NGF) and its high affinity receptor tyrosine kinase A receptor (TRKA) have been associated with the development of several types of cancer, including EOC; both NGF and TRKA levels are elevated in this pathology. EOC presents high angiogenesis and several molecules have been reported to induce this process. NGF increases angiogenesis through its TRKA receptor on endothelial cells, and by indirectly inducing vascular endothelial growth factor expression. Other molecules controlled by NGF include ciclooxigenase-2, disintegrin and metalloproteinase domain-containing protein 17 (ADAM17) and calreticulin (CRT), proteins involved in crucial processes needed for EOC progression. These molecules could be modified through microRNA regulation, which could be regulated by NGF. MicroRNAs are th