Artículos de revistas
Delphinidin-rich maqui berry extract (Delphinol®) lowers fasting and postprandial glycemia and insulinemia in prediabetic individuals during oral glucose tolerance tests
Fecha
2016Registro en:
BioMed Research International, Volumen 2016,
23146141
23146133
10.1155/2016/9070537
Autor
Alvarado, Jorge L.
Leschot, Andrés
Olivera-Nappa, Álvaro
Salgado, Ana María
Rioseco, Hernán
Lyon, Carolina
Vigil, Pilar
Institución
Resumen
© 2016 Jorge L. Alvarado et al. Delphinidin anthocyanins have previously been associated with the inhibition of glucose absorption. Blood glucose lowering effects have been ascribed to maqui berry (Aristotelia chilensis) extracts in humans after boiled rice consumption. In this study, we aimed to explore whether a standardized delphinidin-rich extract from maqui berry (Delphinol) affects glucose metabolism in prediabetic humans based on glycemia and insulinemia curves obtained from an oral glucose tolerance test (OGTT) after a challenge with pure glucose. Volunteers underwent four consecutive OGTTs with at least one week washout period, in which different doses of Delphinol were administered one hour before glucose intake. Delphinol significantly and dose-dependently lowered basal glycemia and insulinemia. Lower doses delayed postprandial glycemic and insulinemic peaks, while higher doses reversed this tendency. Glycemia peaks were dose-dependently lowered, while insulinemia peaks were