dc.creator | Urra, Felix | |
dc.creator | Weiss López, Boris | |
dc.creator | Araya Maturana, Ramiro | |
dc.date.accessioned | 2019-03-18T11:55:32Z | |
dc.date.available | 2019-03-18T11:55:32Z | |
dc.date.created | 2019-03-18T11:55:32Z | |
dc.date.issued | 2016 | |
dc.identifier | Current Pharmaceutical Design, Volumen 22, Issue 39, 2018, Pages 5998-6008 | |
dc.identifier | 18734286 | |
dc.identifier | 13816128 | |
dc.identifier | 10.2174/1381612822666160719122626 | |
dc.identifier | https://repositorio.uchile.cl/handle/2250/166980 | |
dc.description.abstract | © 2016 Bentham Science Publishers. Recent evidence highlights that energy requirements of cancer cells vary greatly from normal cells and they exhibit different metabolic phenotypes with variable participation of both glycolysis and oxidative phosphorylation (OXPHOS). Interestingly, mitochondrial electron transport chain (ETC) has been identified as an essential component in bioenergetics, biosynthesis and redox control during proliferation and metastasis of cancer cells. This dependence converts ETC of cancer cells in a promising target to design small molecules with anti-cancer actions. Several small molecules have been described as ETC inhibitors with different consequences on mitochondrial bioenergetics, viability and proliferation of cancer cells, when the substrate availability is controlled to favor either the glycolytic or OXPHOS pathway. These ETC inhibitors can be grouped as 1) inhibitors of a respiratory complex (e.g. rotenoids, vanilloids, alkaloids, biguanides and polyphen | |
dc.language | en | |
dc.publisher | Bentham Science Publishers B.V. | |
dc.rights | http://creativecommons.org/licenses/by-nc-nd/3.0/cl/ | |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Chile | |
dc.source | Current Pharmaceutical Design | |
dc.subject | Anti-cancer agents | |
dc.subject | Glutamine metabolism | |
dc.subject | Metabolic remodeling | |
dc.subject | Mitochondrial impairment | |
dc.subject | Oxidative phosphorylation | |
dc.subject | Reductive carboxylation | |
dc.subject | Respiratory complexes | |
dc.subject | Slow-cycling cancer cells | |
dc.title | Determinants of anti-cancer effect of mitochondrial electron transport chain inhibitors: Bioenergetic profile and metabolic flexibility of cancer cells | |
dc.type | Artículo de revista | |