Artículos de revistas
Matrix metalloproteinases as regulators of periodontal inflammation
Fecha
2017Registro en:
International Journal of Molecular Sciences, Volumen 18, Issue 2, 2018,
14220067
16616596
10.3390/ijms18020440
Autor
Franco, Cavalla
Patricia, Hernández Rios
Timo, Sorsa
Claudia, Biguetti
Marcela, Hernández
Institución
Resumen
© 2017 by the authors; licensee MDPI, Basel, Switzerland. Periodontitis are infectious diseases characterized by immune-mediated destruction of periodontal supporting tissues and tooth loss. Matrix metalloproteinases (MMPs) are key proteases involved in destructive periodontal diseases. The study and interest in MMP has been fuelled by emerging evidence demonstrating the broad spectrum of molecules that can be cleaved by them and the myriad of biological processes that they can potentially regulate. The huge complexity of MMP functions within the ‘protease web’ is crucial for many physiologic and pathologic processes, including immunity, inflammation, bone resorption, and wound healing. Evidence points out that MMPs assemble in activation cascades and besides their classical extracellular matrix substrates, they cleave several signalling molecules—such as cytokines, chemokines, and growth factors, among others—regulating their biological functions and/or bioavailability during periodon