Artículo de revista
Fixed-points in random Boolean networks: The impact of parallelism in the Barabási–Albert scale-free topology case
Fecha
2016Registro en:
BioSystems, Volumen 150,
18728324
03032647
10.1016/j.biosystems.2016.10.003
Autor
Moisset de Espanés, P.
Osses, A.
Rapaport, I.
Institución
Resumen
© 2016 Elsevier Ireland LtdFixed points are fundamental states in any dynamical system. In the case of gene regulatory networks (GRNs) they correspond to stable genes profiles associated to the various cell types. We use Kauffman's approach to model GRNs with random Boolean networks (RBNs). In this paper we explore how the topology affects the distribution of the number of fixed points in randomly generated networks. We also study the size of the basins of attraction of these fixed points if we assume the α-asynchronous dynamics (where every node is updated independently with probability 0 ≤ α ≤ 1). It is well-known that asynchrony avoids the cyclic attractors into which parallel dynamics tends to fall. We observe the remarkable property that, in all our simulations, if for a given RBN with Barabási–Albert topology and α-asynchronous dynamics an initial configuration reaches a fixed point, then every configuration also reaches a fixed point. By contrast, in the parallel regime, the per