Artículo de revista
Hormone resuscitation therapy for brain-dead donors – is insulin beneficial or detrimental?
Fecha
2016Registro en:
Clinical Transplantation, Volumen 30, Issue 7, 2018, Pages 754-759
13990012
09020063
10.1111/ctr.12742
Autor
Novitzky, Dimitri
Mi, Zhibao
Videla Cabrera, Luis
Collins, Joseph F.
Cooper, David K.C.
Institución
Resumen
© 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd Hormonal replacement therapy to brain-dead potential organ donors remains controversial. A retrospective study was carried out of hormonal therapy on procurement of organs in 63 593 donors in whom information on thyroid hormone therapy (triiodothyronine or levothyroxine [T3/T4]) was available. In 40 124 donors, T3/T4 and all other hormonal therapy were recorded. The percentage of all organs procured, except livers, was greater when T3/T4 had been administered. An independent beneficial effect of antidiuretic hormone (ADH) was also clear. Corticosteroids were less consistently beneficial (most frequently when T3/T4 had not been administered), although never detrimental. Insulin was almost never beneficial and at times was associated with a reduced yield of organs, particularly of the pancreas and intestine, an observation that does not appear to have been reported previously. In addition, there was reduced survival at 12 m