dc.creatorCarrillo, Simón A.
dc.creatorAnguita Salinas, Consuelo
dc.creatorPeña, Oscar A.
dc.creatorMorales, Rodrigo A.
dc.creatorMuñoz Sánchez, Salomé
dc.creatorMuñoz Montecinos, Carlos Humberto.
dc.creatorParedes Zúñiga, Susana
dc.creatorTapia, Karina
dc.creatorAllende Connelly, Miguel
dc.date.accessioned2019-03-18T11:54:18Z
dc.date.available2019-03-18T11:54:18Z
dc.date.created2019-03-18T11:54:18Z
dc.date.issued2016
dc.identifierJournal of cellular biochemistry, Volumen 117, Issue 8, 2018, Pages 1880-1889
dc.identifier10974644
dc.identifier10.1002/jcb.25487
dc.identifierhttps://repositorio.uchile.cl/handle/2250/166797
dc.description.abstract© 2016 Wiley Periodicals, Inc. In vertebrates, damage to mechanosensory hair cells elicits an inflammatory response, including rapid recruitment of macrophages and neutrophils. While hair cells in amniotes usually become permanently lost, they readily regenerate in lower vertebrates such as fish. Damage to hair cells of the fish lateral line is followed by inflammation and rapid regeneration; however the role of immune cells in this process remains unknown. Here, we show that recruited macrophages are required for normal regeneration of lateral line hair cells after copper damage. We found that genetic ablation or local ablation using clodronate liposomes of macrophages recruited to the site of injury, significantly delays hair cell regeneration. Neutrophils, on the other hand, are not needed for this process. We anticipate our results to be a starting point for a more detailed description of extrinsic signals important for regeneration of mechanosensory cells in vertebrates. J. Cell.
dc.languageen
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
dc.sourceJournal of cellular biochemistry
dc.subjectCLODRONATE
dc.subjectINFLAMMATION
dc.subjectMACROPHAGE
dc.subjectREGENERATION
dc.subjectRESOLUTION
dc.subjectZEBRAFISH
dc.titleMacrophage Recruitment Contributes to Regeneration of Mechanosensory Hair Cells in the Zebrafish Lateral Line
dc.typeArtículo de revista


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