dc.creatorAlvarez, Carolina
dc.creatorAravena, Andrés
dc.creatorTapia, Teresa
dc.creatorRozenblum, Ester
dc.creatorSolís, Luisa
dc.creatorCorvalán, Alejandro
dc.creatorCamus, Mauricio
dc.creatorAcevedo Alvarez, Manuel
dc.creatorMunroe, David
dc.creatorMaass Sepúlveda, Alejandro
dc.creatorCarvallo, Pilar
dc.date.accessioned2019-03-18T11:54:18Z
dc.date.available2019-03-18T11:54:18Z
dc.date.created2019-03-18T11:54:18Z
dc.date.issued2016
dc.identifierBMC Cancer, Volumen 16, Issue 1, 2018,
dc.identifier14712407
dc.identifier10.1186/s12885-016-2261-x
dc.identifierhttps://repositorio.uchile.cl/handle/2250/166793
dc.description.abstract© 2016 Alvarez et al.Background: Array CGH analysis of breast tumors has contributed to the identification of different genomic profiles in these tumors. Loss of DNA repair by BRCA1 functional deficiency in breast cancer has been proposed as a relevant contribution to breast cancer progression for tumors with no germline mutation. Identifying the genomic alterations taking place in BRCA1 not expressing tumors will lead us to a better understanding of the cellular functions affected in this heterogeneous disease. Moreover, specific genomic alterations may contribute to the identification of potential therapeutic targets and offer a more personalized treatment to breast cancer patients. Methods: Forty seven tumors from hereditary breast cancer cases, previously analyzed for BRCA1 expression, and screened for germline BRCA1 and 2 mutations, were analyzed by Array based Comparative Genomic Hybridization (aCGH) using Agilent 4x44K arrays. Overall survival was established for tumors in diffe
dc.languageen
dc.publisherBioMed Central Ltd.
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
dc.sourceBMC Cancer
dc.subjectArray CGH
dc.subjectBRCAX
dc.subjectBreast cancer
dc.subjectGenomic gains
dc.subjectGenomic losses
dc.subjectOncogenes
dc.subjectTumor suppressor
dc.titleDifferent Array CGH profiles within hereditary breast cancer tumors associated to BRCA1 expression and overall survival
dc.typeArtículos de revistas


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