Chile
| Artículo de revista
Injury to the nervous system: A look into the ER
dc.creator | Valenzuela, Vicente | |
dc.creator | Oñate, Maritza | |
dc.creator | Hetz Flores, Claudio | |
dc.creator | Court, Felipe A. | |
dc.date.accessioned | 2019-03-18T11:54:16Z | |
dc.date.available | 2019-03-18T11:54:16Z | |
dc.date.created | 2019-03-18T11:54:16Z | |
dc.date.issued | 2016 | |
dc.identifier | Brain Research, Volumen 1648, | |
dc.identifier | 18726240 | |
dc.identifier | 00068993 | |
dc.identifier | 10.1016/j.brainres.2016.04.053 | |
dc.identifier | https://repositorio.uchile.cl/handle/2250/166778 | |
dc.description.abstract | © 2016 Elsevier B.V.Injury to the central or peripheral nervous systems leads to the loss of cognitive and/or sensorimotor capabilities that still lack an effective treatment. Although injury to the nervous system involves multiple and complex molecular factors, alteration to protein homeostasis is emerging as a relevant pathological mechanism. In particular, chronic endoplasmic reticulum (ER) stress is proposed as a possible driver of neuronal dysfunction in conditions such as spinal cord injury, stroke and damage to peripheral nerves. Importantly, manipulation of the unfolded protein response (UPR), a homeostatic pathway engaged by ER stress, has proved effective in improving cognitive and motor recovery after nervous system injury. Here we provide an overview on recent findings depicting a functional role of the UPR to the functional recovery after injury in the peripheral and central nervous systems. This article is part of a Special Issue entitled SI:ER stress. | |
dc.language | en | |
dc.publisher | Elsevier B.V. | |
dc.rights | http://creativecommons.org/licenses/by-nc-nd/3.0/cl/ | |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Chile | |
dc.source | Brain Research | |
dc.subject | Brain injury | |
dc.subject | ER stress | |
dc.subject | Peripheral nerve injury | |
dc.subject | Spinal cord injury | |
dc.subject | Unfolded protein response | |
dc.title | Injury to the nervous system: A look into the ER | |
dc.type | Artículo de revista |