Chile | Artículo de revista
dc.creatorValenzuela, Vicente
dc.creatorOñate, Maritza
dc.creatorHetz Flores, Claudio
dc.creatorCourt, Felipe A.
dc.date.accessioned2019-03-18T11:54:16Z
dc.date.available2019-03-18T11:54:16Z
dc.date.created2019-03-18T11:54:16Z
dc.date.issued2016
dc.identifierBrain Research, Volumen 1648,
dc.identifier18726240
dc.identifier00068993
dc.identifier10.1016/j.brainres.2016.04.053
dc.identifierhttps://repositorio.uchile.cl/handle/2250/166778
dc.description.abstract© 2016 Elsevier B.V.Injury to the central or peripheral nervous systems leads to the loss of cognitive and/or sensorimotor capabilities that still lack an effective treatment. Although injury to the nervous system involves multiple and complex molecular factors, alteration to protein homeostasis is emerging as a relevant pathological mechanism. In particular, chronic endoplasmic reticulum (ER) stress is proposed as a possible driver of neuronal dysfunction in conditions such as spinal cord injury, stroke and damage to peripheral nerves. Importantly, manipulation of the unfolded protein response (UPR), a homeostatic pathway engaged by ER stress, has proved effective in improving cognitive and motor recovery after nervous system injury. Here we provide an overview on recent findings depicting a functional role of the UPR to the functional recovery after injury in the peripheral and central nervous systems. This article is part of a Special Issue entitled SI:ER stress.
dc.languageen
dc.publisherElsevier B.V.
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
dc.sourceBrain Research
dc.subjectBrain injury
dc.subjectER stress
dc.subjectPeripheral nerve injury
dc.subjectSpinal cord injury
dc.subjectUnfolded protein response
dc.titleInjury to the nervous system: A look into the ER
dc.typeArtículo de revista


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