Reduction of serum advanced glycation end-products with a low calorie mediterranean diet Reducción sérica de productos finales de glicación avanzada séricos con una dieta baja en calorías tipo mediterráneo

Abstract

© 2015, Grupo Aula Medica S.A. All rights reserved. Dietary intake of advanced glycation end-products (AGEs) increases circulating and tissue levels of these substances, contributing to a state of increased oxidative stress and inflammation. A low dietary AGE intervention has been shown to reduce body AGE content. Mediterranean diets (MD) are theoretically considered low in AGEs, but the specific effects of a MD on AGEs serum levels has not been tested. Methodology: forty-seven overweight and obese premenopausal women underwent a three-month calorie restriction treatment (20 kcal/kg initial weight) with a Mediterranean-type diet that excluded wine intake. The adherence to the MD was assessed before and at the end of treatment using an on-line questionnaire, which scores from 0 to 14 (minimal to maximal adherence). Body composition, insulin resistance, lipoproteins and carboxymethyl- lisine (CML) serum levels were measured at both time periods. Serum CML was assessed through ELISA (enzy