A novel caveolin-1/p85α/Rab5/Tiam1/Rac1 signaling axis in tumor cell migration and invasion

dc.creatorDíaz, Jorge
dc.creatorMendoza, Pablo
dc.creatorSilva, Patricio
dc.creatorQuest, Andrew F. G.
dc.creatorTorres, Vicente A.
dc.date.accessioned2019-03-15T16:08:00Z
dc.date.available2019-03-15T16:08:00Z
dc.date.created2019-03-15T16:08:00Z
dc.date.issued2014
dc.identifierCommunicative and Integrative Biology, Volumen 7, Issue 5, 2018, Pages 1-3
dc.identifier19420889
dc.identifier10.4161/19420889.2014.972850
dc.identifierhttps://repositorio.uchile.cl/handle/2250/166341
dc.description.abstract© Jorge Díaz, Pablo endoza, Patricio Silva, Andrew FG Quest, and Vicente A Torres. The small GTPase Rab5 has been frequently studied in the context of intracellular trafficking, but evidence obtained more recently has implicated Rab5 as a critical regulator of cell adhesion, migration and invasion in both normal and tumor cells. These recent findings showing that Rab5 promotes Rac1 activation and focal adhesion dynamics have highlighted the question as to what the upstream regulators of Rab5 activity might be and how these are connected to cell migration. The efforts to shed light on this issue identified in metastatic cancer cells a novel Caveolin-1/p85α/Rab5/Tiam1/Rac1 signaling axis relevant to cancer cell migration and invasion. In this addendum, we highlight aspects concerning Rab5 regulation in this context.
dc.languageen
dc.publisherLandes Bioscience
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
dc.sourceCommunicative and Integrative Biology
dc.subjectCaveolin-1
dc.subjectCell migration
dc.subjectInvasion
dc.subjectp85α
dc.subjectRab5
dc.subjectRac1
dc.titleA novel caveolin-1/p85α/Rab5/Tiam1/Rac1 signaling axis in tumor cell migration and invasion
dc.typeArtículo de revista


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