dc.creator | Tapia Opazo, Gladys | |
dc.creator | Valenzuela, Rodrigo | |
dc.creator | Espinosa, Alejandra | |
dc.creator | Romanque, Pamela | |
dc.creator | Dossi, Camila | |
dc.creator | González Mañán, Daniel Alonso | |
dc.creator | Videla Cabrera, Luis | |
dc.creator | D'Espessailles Tapia, Amanda | |
dc.date.accessioned | 2019-03-15T16:06:41Z | |
dc.date.available | 2019-03-15T16:06:41Z | |
dc.date.created | 2019-03-15T16:06:41Z | |
dc.date.issued | 2014 | |
dc.identifier | Molecular Nutrition and Food Research, Volumen 58, Issue 6, 2018, Pages 1333-1341 | |
dc.identifier | 16134133 | |
dc.identifier | 16134125 | |
dc.identifier | 10.1002/mnfr.201300458 | |
dc.identifier | https://repositorio.uchile.cl/handle/2250/166182 | |
dc.description.abstract | Scope: Dietary n-3 long-chain PUFAs (n-3 LCPUFAs) supplementation was studied in an HFD-induced (HFD is high-fat diet) steatosis and inflammation in relation to peroxisome proliferator-activated receptor alpha (PPAR-α) and nuclear factor κB (NF-κB) signaling. Methods and results: Male C57BL/6J mice received (i) control diet (10% fat, 20% protein, 70% carbohydrate), (ii) control diet plus n-3 LCPUFAs (daily doses of 108 mg/kg body weight of eicosapentaenoic acid plus 92 mg/kg body weight of docosahexaenoic acid), (iii) HFD (60% fat, 20% protein, 20% carbohydrate), or (iv) HFD plus n-3 LCPUFAs for 12 wk. PPAR-α, tumor necrosis factor alpha (TNF-α), and IL-1β mRNA expression, acyl-CoA oxidase 1 (ACOX1), and carnitine-acyl-CoA transferase 1 (CAT-I) protein contents, and NF-κB DNA binding activity were measured. HFD significantly decreased liver PPAR-α, ACOX1, and CAT-I levels with NF-κB activation, higher TNF-α and IL-1β expression, and steatosis development. These changes were either redu | |
dc.language | en | |
dc.publisher | Wiley-VCH Verlag | |
dc.rights | http://creativecommons.org/licenses/by-nc-nd/3.0/cl/ | |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Chile | |
dc.source | Molecular Nutrition and Food Research | |
dc.subject | High-fat diet | |
dc.subject | Liver steatosis | |
dc.subject | n-3 long-chain PUFA | |
dc.subject | Nuclear factor κB | |
dc.subject | Peroxisome proliferator-activated receptor alpha | |
dc.title | N-3 long-chain PUFA supplementation prevents high fat diet induced mouse liver steatosis and inflammation in relation to PPAR-α upregulation and NF-κB DNA binding abrogation | |
dc.type | Artículo de revista | |