dc.creator | Fernández Verdejo, Rodrigo | |
dc.creator | Casas, M. | |
dc.creator | Galgani Fuentes, José | |
dc.creator | Jaimovich Pérez, Enrique | |
dc.creator | Buvinic Radic, Sonja | |
dc.date.accessioned | 2019-03-15T16:06:12Z | |
dc.date.available | 2019-03-15T16:06:12Z | |
dc.date.created | 2019-03-15T16:06:12Z | |
dc.date.issued | 2014 | |
dc.identifier | International Journal of Sports Medicine, Volumen 35, Issue 4, 2018, Pages 273-279 | |
dc.identifier | 14393964 | |
dc.identifier | 01724622 | |
dc.identifier | 10.1055/s-0033-1353147 | |
dc.identifier | https://repositorio.uchile.cl/handle/2250/166140 | |
dc.description.abstract | Active skeletal muscle synthesizes and releases interleukin-6 (IL-6), which plays important roles in the organism's adaptation to exercise. Autocrine/paracrine ATP signaling has been shown to modulate IL-6 expression. The aim of this study was to determine whether a period of physical activity modifies the ATP-induced IL-6 expression. BalbC mice were either subject to 5 weeks voluntary wheel running (VA) or kept sedentary (SED). Flexor digitorum brevis muscles were dissected, stimulated with different ATP concentrations (0-100 μM) and IL-6 mRNA levels were measured using qPCR. ATP evoked a concentration-dependent rise in IL-6 mRNA in both SED and VA mice. VA mice however, had significantly higher ATP sensitivity (pD2 pharmacological values: VA=5.58±0.02 vs. SED=4.95±0.04, p<0.05). Interestingly, in VA mice we observed a positive correlation between the level of physical activity and the IL-6 mRNA increase following fiber stimulation with 10μM ATP. In addition, there were lower P2Y2- an | |
dc.language | en | |
dc.publisher | Georg Thieme Verlag | |
dc.rights | http://creativecommons.org/licenses/by-nc-nd/3.0/cl/ | |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Chile | |
dc.source | International Journal of Sports Medicine | |
dc.subject | interleukin-6 | |
dc.subject | nucleotide receptors | |
dc.subject | Physical activity | |
dc.subject | voluntary wheel running | |
dc.title | Exercise sensitizes skeletal muscle to extracellular ATP for IL-6 expression in mice | |
dc.type | Artículo de revista | |