dc.creator | Miranda, Hugo F. | |
dc.creator | Noriega, Viviana | |
dc.creator | Zanetta, Pilar | |
dc.creator | Prieto, Juan Carlos | |
dc.date.accessioned | 2019-03-15T16:05:57Z | |
dc.date.available | 2019-03-15T16:05:57Z | |
dc.date.created | 2019-03-15T16:05:57Z | |
dc.date.issued | 2013 | |
dc.identifier | Journal of Oral and Facial Pain and Headache, Volumen 27, Issue 4, 2018, Pages 361-366 | |
dc.identifier | 23330376 | |
dc.identifier | 23330384 | |
dc.identifier | 10.11607/jop.1167 | |
dc.identifier | https://repositorio.uchile.cl/handle/2250/166082 | |
dc.description.abstract | © Quintessence. Aims: To evaluate the nature of the antinociceptive interaction of systemic administration of a combination of the anticonvulsant gabapentin with the antidepressant nortriptyline, by isobolographic analysis in the formalin orofacial pain test of mice. Methods: The study was carried out in 168 male CF-1 mice weighing 30 g, and the protocol was to test each drug (at dosages of 1, 3, 10, 30, and 100 mg/kg of gabapentin and 0.1, 1, 3, 10, and 30 mg/kg of nortriptyline; ip) alone and in combination. The isobolographic assay has two phases: phase 1 corresponds to the 5-minute period starting immediately after the formalin injection and reflects a tonic acute pain due to peripheral nociceptor sensitization; phase 2 is recorded as the 10-minute period starting 20 minutes after the formalin injection and reflects an inflammatory pain state. Results were analyzed by Student t test for independent means. Results: Gabapentin was 1.61 times more potent in phase 2 than in phase 1, an | |
dc.language | en | |
dc.publisher | Quintessence Publishing Co. Inc. | |
dc.rights | http://creativecommons.org/licenses/by-nc-nd/3.0/cl/ | |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Chile | |
dc.source | Journal of Oral and Facial Pain and Headache | |
dc.subject | Gabapentin | |
dc.subject | Isobolographic analysis | |
dc.subject | Nortriptyline | |
dc.subject | Orofacial pain | |
dc.subject | Synergism | |
dc.title | Isobolographic analysis in mice of the interaction of gabapentin and nortriptyline in relieving orofacial pain | |
dc.type | Artículos de revistas | |