Artículos de revistas
Impact of genetic ancestry and sociodemographic status on the clinical expression of systemic lupus erythematosus in American Indian-European populations
Fecha
2012Registro en:
Arthritis and Rheumatism, Volumen 64, Issue 11, 2018, Pages 3687-3694
00043591
15290131
10.1002/art.34650
Autor
Sánchez, Elena
Rasmussen, Astrid
Riba, Laura
Acevedo Vásquez, Eduardo
Kelly, Jennifer A.
Langefeld, Carl D.
Williams, Adrianne H.
Ziegler, Julie T.
Comeau, Mary E.
Marion, Miranda C.
García-De La Torre, Ignacio
Maradiaga Ceceña, Marco A.
Cardiel, Mario H.
Institución
Resumen
Objective American Indian-Europeans, Asians, and African Americans have an excess morbidity from systemic lupus erythematosus (SLE) and a higher prevalence of lupus nephritis than do Caucasians. The aim of this study was to analyze the relationship between genetic ancestry and sociodemographic characteristics and clinical features in a large cohort of American Indian-European SLE patients. Methods A total of 2,116 SLE patients of American Indian-European origin and 4,001 SLE patients of European descent for whom we had clinical data were included in the study. Genotyping of 253 continental ancestry-informative markers was performed on the Illumina platform. Structure and Admixture software were used to determine genetic ancestry proportions of each individual. Logistic regression was used to test the association between genetic ancestry and sociodemographic and clinical characteristics. Odds ratios (ORs) were calculated with 95% confidence intervals (95% CIs). Results The average Ameri