Artículos de revistas
Long-term exposure to high-altitude chronic hypoxia during gestation induces neonatal pulmonary hypertension at sea level
Fecha
2010Registro en:
American Journal of Physiology - Regulatory Integrative and Comparative Physiology, Volumen 299, Issue 6, 2018,
03636119
15221490
10.1152/ajpregu.00123.2010
Autor
Herrera, Emilio A.
Riquelme, Raquel A.
Ebensperger Darrouy, Germán
Reyes, Roberto V.
Ulloa, César E.
Cabello, Gertrudis
Krause, Bernardo J.
Parer, Julian T.
Giussani, Dino A.
Llanos Mansilla, Jorge
Institución
Resumen
We determined whether postnatal pulmonary hypertension induced by 70% of pregnancy at high altitude (HA) persists once the offspring return to sea level and investigated pulmonary vascular mechanisms operating under these circumstances. Pregnant ewes were divided into two groups: conception, pregnancy, and delivery at low altitude (580 m, LLL) and conception at low altitude, pregnancy at HA (3,600 m) from 30% of gestation until delivery, and return to lowland (LHL). Pulmonary arterial pressure (PAP) was measured in vivo. Vascular reactivity and morphometry were assessed in small pulmonary arteries (SPA). Protein expression of vascular mediators was determined. LHL lambs had higher basal PAP and a greater increment in PAP after NG-nitro-L- arginine methyl ester (20.9 ± 1.1 vs. 13.7 ± 0.5 mmHg; 39.9 ± 5.0 vs. 18.3 ± 1.3 mmHg, respectively). SPA from LHL had a greater maximal contraction to K+ (1.34 ± 0.05 vs. 1.16 ± 0.05 N/m), higher sensitivity to endothelin-1 and nitroprusside, and per
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