dc.creatorSuazo, José
dc.creatorSantos, José Luis
dc.creatorJara, Lilian
dc.creatorBlanco, Rafael
dc.date.accessioned2019-03-11T13:00:08Z
dc.date.available2019-03-11T13:00:08Z
dc.date.created2019-03-11T13:00:08Z
dc.date.issued2010
dc.identifierAmerican Journal of Medical Genetics, Part A, Volumen 152, Issue 8, 2018, Pages 2011-2016
dc.identifier15524825
dc.identifier15524833
dc.identifier10.1002/ajmg.a.33528
dc.identifierhttps://repositorio.uchile.cl/handle/2250/165043
dc.description.abstractBased on association and sequencing studies, investigators have postulated muscle segment homeobox 1 (MSX1) as a strong candidate gene involved in the causation of nonsyndromic cleft lip with or without cleft palate (NSCLP). Parent-of-origin effects have been suggested for some NSCLP candidate genes but not for MSX1. The aims of the present study were to test for allele/haplotype associations applying the transmission disequilibrium test (TDT) and the transmission asymmetry test (TAT) to evaluate the possible parent-of-origin effects of MSX1 in Chilean patients with NSCLP. We analyzed five SNPs (rs6446693/c.-425G>T/c.-35G>A/rs3775261/rs12532) located from 6.3 kb upstream to 3′ UTR in a sample of 150 unrelated NSCLP case-parent trios. Four haplotypes showed overtransmission from parents to affected progeny, but individual SNPs did not. Two haplotypes presented allele combination C-G-A-G (P=0.035) and two T-G-C-A (P=0.044) (SNP order rs6446693/c.-35G>A/rs3775261/ rs12532). The rs12532 A
dc.languageen
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
dc.sourceAmerican Journal of Medical Genetics, Part A
dc.subjectAssociation
dc.subjectMSX1
dc.subjectNon-syndromic cleft lip/palate
dc.subjectParent-of-origin effects
dc.titleParent-of-origin effects for MSX1 in a Chilean population with nonsyndromic cleft lip/palate
dc.typeArtículo de revista


Este ítem pertenece a la siguiente institución