| dc.creator | Moore, C. | |
| dc.creator | Sauma Mahaluf, Daniela | |
| dc.creator | Reyes, P. A. | |
| dc.creator | Morales, J. | |
| dc.creator | Rosemblatt Silber, Mario César | |
| dc.creator | Bono Merino, María Rosa | |
| dc.creator | Fierro, J. A. | |
| dc.date.accessioned | 2019-03-11T12:59:12Z | |
| dc.date.available | 2019-03-11T12:59:12Z | |
| dc.date.created | 2019-03-11T12:59:12Z | |
| dc.date.issued | 2010 | |
| dc.identifier | Transplantation Proceedings, Volumen 42, Issue 1, 2018, Pages 371-375 | |
| dc.identifier | 00411345 | |
| dc.identifier | 10.1016/j.transproceed.2009.12.044 | |
| dc.identifier | https://repositorio.uchile.cl/handle/2250/164949 | |
| dc.description.abstract | Background: CD4+CD25+Foxp3+ regulatory T cells (Treg) play an essential role in immune tolerance, suppressing responses against self-antigens. Additionally, Treg play an important role in maintaining immunosuppression to alloantigens as well as to other antigens. It is well known that in the gut, a subset of dendritic cells produces retinoic acid (RA), which together with transforming growth factor (TGF-β) is able to differentiate naïve T cells into Treg. The aim of this study was to establish the role of antigen-presenting cells (APC) in the differentiation of allogeneic Tregs under the effect of RA and TGF-β. Methods: Splenic CD4+CD25- naïve T cells from C57BL/6 mice were co-cultured with splenic CD11c-enriched APC from Balb/c mice in the presence of TGF-β, RA, and interleukin (IL-2). After 6 days of culture, cells were analyzed for the expression of Foxp3 by flow cytometry. Additionally, we investigated the role of B cells and dendritic cells (DCs) and their stimulatory capacity in | |
| dc.language | en | |
| dc.rights | http://creativecommons.org/licenses/by-nc-nd/3.0/cl/ | |
| dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Chile | |
| dc.source | Transplantation Proceedings | |
| dc.subject | Surgery | |
| dc.subject | Transplantation | |
| dc.title | Dendritic Cells and B Cells Cooperate in the Generation of CD4+CD25+FOXP3+ Allogeneic T Cells | |
| dc.type | Artículo de revista | |
