dc.creatorRodríguez, Juan Pablo
dc.creatorAstudillo, Pablo
dc.creatorRíos, Susana
dc.creatorPino, Ana María
dc.date.accessioned2019-03-11T12:56:50Z
dc.date.available2019-03-11T12:56:50Z
dc.date.created2019-03-11T12:56:50Z
dc.date.issued2008
dc.identifierCurrent Stem Cell Research and Therapy, Volumen 3, Issue 3, 2018, Pages 208-218
dc.identifier1574888X
dc.identifier10.2174/157488808785740325
dc.identifierhttps://repositorio.uchile.cl/handle/2250/164675
dc.description.abstractMesenchymal Stem Cells (MSCs) from bone marrow stroma are capable of differentiating into osteoblasts and adipocytes, among other cell phenotypes. In normal bone marrow osteoblastic and adipocytic cell differentiation occur in favor of bone formation, but this relationship appears disrupted in several bone diseases. In osteoporosis increased bone marrow adipocyte production is counterbalanced by diminished production of osteogenic cells. Since osteoblats and adipocytes originate from a common MSC precursor cell, quantitative and qualitative stem cell defects may underlie the modified number and function of differentiated cells. This review analyzes experimental evidence which describes differences in the osteogenic/adipogenic potentials of human bone marrow MSCs obtained from control and osteoporotic post-menopausal women. The protective effect exerted by locally generated factors, such as estradiol and leptin, on MSCs differentiation was analyzed, because altered bioavailability of th
dc.languageen
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
dc.sourceCurrent Stem Cell Research and Therapy
dc.subjectAdipogenesis
dc.subjectEstrogens
dc.subjectLeptin
dc.subjectMesenchymal stem cells
dc.subjectOsteogepesis
dc.subjectOsteoporosis
dc.subjectPPARγ
dc.titleInvolvement of adipogenic potential of human bone marrow mesenchymal stem cells (MSCs) in osteoporosis
dc.typeArtículo de revista


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