dc.creatorSmith, P.C.
dc.creatorGuerrero, J.
dc.creatorTobar, N.
dc.creatorCáceres, M.
dc.creatorGonzález, M. J.
dc.creatorMartínez, J.
dc.date.accessioned2019-03-11T12:56:48Z
dc.date.available2019-03-11T12:56:48Z
dc.date.created2019-03-11T12:56:48Z
dc.date.issued2009
dc.identifierJournal of Periodontal Research, Volumen 44, Issue 1, 2018, Pages 73-80
dc.identifier00223484
dc.identifier10.1111/j.1600-0765.2007.01081.x
dc.identifierhttps://repositorio.uchile.cl/handle/2250/164668
dc.description.abstractBackground and Objectives: Membrane type 1-matrix metalloproteinase (MT1-MMP) is a collagenolytic enzyme involved in connective tissue remodeling. In periodontal tissues, either cytokines or growth factors regulate the production of proteolytic enzymes. Mice deficient in epidermal growth factor receptor (EGFR) show a reduced expression of MT1-MMP, suggesting that this receptor may play an important role in MT1-MMP production. The present study evaluated the role of the inflammatory cytokine tumor necrosis factor-α (TNF-α) and EGFR in the production of MT1-MMP in gingival fibroblasts. Material and Methods: Primary cultures of human gingival fibroblasts were cultured over plastic or a type I collagen matrix and stimulated with TNF-α and EGF. A selective EGFR inhibitor (AG1478) was used to interfere with this signaling pathway. Production of MT1-MMP and activation of proMMP-2 were studied using Western blot and gelatin zymography, respectively. Activation of EGFR signaling was assessed th
dc.languageen
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
dc.sourceJournal of Periodontal Research
dc.subjectEpidermal growth factor receptor
dc.subjectFibroblast
dc.subjectMembrane type 1-matrix metalloproteinase
dc.subjectTumor necrosis factor-α
dc.titleTumor necrosis factor-α-stimulated membrane type 1-matrix metalloproteinase production is modulated by epidermal growth factor receptor signaling in human gingival fibroblasts
dc.typeArtículo de revista


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