dc.creatorMancilla, Alejandra
dc.creatorCruz Vargas, Victor Ignacio
dc.creatorIzquierdo, Luis
dc.date.accessioned2019-01-29T17:57:08Z
dc.date.available2019-01-29T17:57:08Z
dc.date.created2019-01-29T17:57:08Z
dc.date.issued1997
dc.identifierBiocell, Volumen 21, Issue 3, 2018, Pages 167-174
dc.identifier03279545
dc.identifierhttp://repositorio.uchile.cl/handle/2250/163939
dc.description.abstractDifferentiation of the nonadherent trophectoderm cells of the mammalian embryo into attachment-competent trophoblast cells appears to be a necessary event for invasion of the uterine stroma. We have used a hanging drop culture system to investigate the involvement of contact with a solid surface and extracellular matrix proteins on mouse trophoblast differentiation. We report that laminin, but not fibronectin, promotes in vitro outgrowth of mouse trophoblast without attachment of the embryo to a solid surface, in a serum free culture medium. This result indicates that, in the presence of a trophoblast differentiation factor, the contact of the embryo with a solid surface is not necessary to obtain in vitro trophoblast differentiation.
dc.languageen
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
dc.sourceBiocell
dc.subjectBlastocyst
dc.subjectLaminin
dc.subjectMouse embryo
dc.subjectTrophoblast
dc.titleLaminin promotes in vitro outgrowth of mouse trophoblast from blastocysts cultured in hanging drop
dc.typeArtículos de revistas


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