dc.creator | Inostroza, Juan | |
dc.creator | Sáenz Iturriaga, Leonardo Enrique | |
dc.creator | Calaf, Gloria | |
dc.creator | Cabello, Gertrudis | |
dc.creator | Parra, Eduardo | |
dc.date.accessioned | 2019-01-29T17:56:54Z | |
dc.date.available | 2019-01-29T17:56:54Z | |
dc.date.created | 2019-01-29T17:56:54Z | |
dc.date.issued | 2005 | |
dc.identifier | Biological Research, Volumen 38, Issue 2-3, 2018, Pages 163-178 | |
dc.identifier | 07169760 | |
dc.identifier | 10.4067/S0716-97602005000200006 | |
dc.identifier | https://repositorio.uchile.cl/handle/2250/163891 | |
dc.description.abstract | The specific signaling connections between the mitogen-activated protein kinases (MAPK) such as c-Jun N-terminal kinase (JNK-1) and phosphatases PP4 and M3/6, affecting the family of early nuclear factors, is complex and remains poorly understood. JNK-1 regulates cellular differentiation, apoptosis and stress responsiveness by up-regulating early nuclear factors such as c-Jun, a member of the activating protein (AP-1) family, and the Early Growth Factor (EGR-1). C-Jun, when phosphorylated by c-Jun N-terminal kinase (JNK-1) associates with c-Fos to form the AP-1 transcription factor that activates gene expression. We have investigated the regulation of the JNK-1 kinase by co-transfecting phosphatases PP4 and M3/6 in prostate cancer cell lines PC-3 and LNCaP, which have been previously stimulated with human EGF or cisplatin. Co-transfections of plasmids expressing the JNK-1 and the serine/threonine phosphatases PP4 resulted in a significant increase in JNK-1 activity in both PC3 and LNCa | |
dc.language | en | |
dc.publisher | Society of Biology of Chile | |
dc.rights | http://creativecommons.org/licenses/by-nc-nd/3.0/cl/ | |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Chile | |
dc.source | Biological Research | |
dc.subject | Kinase JNK-1 | |
dc.subject | Phosphatase PP4 | |
dc.subject | Prostate cancer | |
dc.title | Role of the phosphatase PP4 in the activation of JNK-1 in prostate carcinoma cell lines PC-3 and LNCaP resulting in increased AP-1 and EGR-1 activity | |
dc.type | Artículos de revistas | |