Artículo de revista
Early detection in saliva of polypeptides associated to isoproterenol-induced mouse parotid hypertrophy
Fecha
2003Registro en:
Biochimica et Biophysica Acta - General Subjects, Volumen 1621, Issue 1, 2018, Pages 41-47
03044165
10.1016/S0304-4165(03)00027-8
Autor
López Solís, Remigio
Puente Díaz, Margarita
Morales Bozo, Irene
Kemmerling Weis, Ulrike
Rojas Díaz, Francisco Rafael
Institución
Resumen
Chronic administration of isoproterenol (IPR) results in a marked hypertrophy and in the induction of a group of putative proline-rich polypeptides in the mouse parotid glands. Some of these polypeptides (pps C-G) have been considered as molecular markers of the parotid gland enlargement. Given the secretory character of polypeptides C-G, the polypeptide composition of mouse saliva was used to monitor the IPR-induced salivary gland hypertrophy. Whole saliva was collected after an oral administration of pilocarpine (PIL). Under those conditions, PIL provoked a massive salivary secretion both in normal control mice and during the whole course of the IPR-induced gland enlargement. Striking changes in the polypeptide composition of saliva obtained from chronically IPR-stimulated animals were observed. Those changes consisted basically in the appearance and progressive increase in concentration of parotid polypeptides C-G and in the progressive diminution in concentration of a couple of nor