dc.creator | Muñoz, Francisco J. | |
dc.creator | Opazo, Carlos | |
dc.creator | Gil-Gómez, Gabriel | |
dc.creator | Tapia, Gladys | |
dc.creator | Fernández, Virginia | |
dc.creator | Valverde, Miguel A. | |
dc.creator | Inestrosa, Nibaldo C. | |
dc.date.accessioned | 2019-01-29T17:51:53Z | |
dc.date.available | 2019-01-29T17:51:53Z | |
dc.date.created | 2019-01-29T17:51:53Z | |
dc.date.issued | 2002 | |
dc.identifier | Journal of Neuroscience, Volumen 22, Issue 8, 2018, Pages 3081-3089 | |
dc.identifier | 02706474 | |
dc.identifier | http://repositorio.uchile.cl/handle/2250/163599 | |
dc.description.abstract | Amyloid β-peptide (Aβ) fibril deposition on cerebral vessels produces cerebral amyloid angiopathy that appears in the majority of Alzheimer's disease patients. An early onset of a cerebral amyloid angiopathy variant called hereditary cerebral hemorrhage with amyloidosis of the Dutch type is caused by a point mutation in Aβ yielding AβGlu22→Gln. The present study addresses the effect of amyloid fibrils from both wild-type and mutated Aβ on vascular cells, as well as the putative protective role of antioxidants on amyloid angiopathy. For this purpose, we studied the cytotoxicity induced by Aβ1-40 Glu22→Gln and Aβ1-40 wild-type fibrils on human venule endothelial cells and rat aorta smooth muscle cells. We observed that AβGlu22→Gln fibrils are more toxic for vascular cells than the wild-type fibrils. We also evaluated the cytotoxicity of Aβ fibrils bound with acetyl-cholinesterase (AChE), a common component of amyloid deposits. Aβ1-40 wild-type-AChE fibrillar complexes, similar to neurona | |
dc.language | en | |
dc.rights | http://creativecommons.org/licenses/by-nc-nd/3.0/cl/ | |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Chile | |
dc.source | Journal of Neuroscience | |
dc.subject | 17β-estradiol | |
dc.subject | Acetylcholinesterase | |
dc.subject | Alzheimer's disease | |
dc.subject | Amyloid | |
dc.subject | CAA | |
dc.subject | Endothelial cells | |
dc.subject | HCHWA-D | |
dc.subject | Oxidative stress | |
dc.subject | Vascular smooth muscle cells | |
dc.subject | Vitamin C | |
dc.subject | Vitamin E | |
dc.title | Vitamin E but not 17β-estradiol protects against vascular toxicity induced by β-amyloid wild type and the dutch amyloid variant | |
dc.type | Artículos de revistas | |