Artículo de revista
Renal damage mediated by oxidative stress: A hypothesis of protective effects of red wine
Fecha
2002Registro en:
Free Radical Biology and Medicine, Volumen 33, Issue 3, 2018, Pages 409-422
08915849
10.1016/S0891-5849(02)00908-5
Autor
Rodrigo Salinas, Ramón
Gacitúa Rivera, Gonzalo Marcelo
Institución
Resumen
Over the last decade, oxidative stress has been implicated in the pathogenesis of a wide variety of seemingly unrelated renal diseases. Epidemiological studies have documented an association of moderate wine consumption with a decreased risk of cardiovascular and neurological diseases; however, similar studies in the kidney are still lacking. The kidney is an organ highly vulnerable to damage caused by reactive oxygen species (ROS), likely due to the abundance of polyunsaturated fatty acids in the composition of renal lipids. ROS are involved in the pathogenic mechanism of conditions such as glomerulosclerosis and tubulointerstitial fibrosis. The health benefits of moderate consumption of red wine can be partly attributed to its antioxidant properties. Indeed, the kidney antioxidant defense system is enhanced after chronic exposure to moderate amounts of wine, a response arising from the combined effects of ethanol and the nonalcoholic components, mainly polyphenols. Polyphenols behave