dc.creator | Mericq, Verónica | |
dc.creator | Gajardo, Héctor | |
dc.creator | Eggers, Martha | |
dc.creator | Avila, Alejandra | |
dc.creator | Cassorla Goluboff, Fernando | |
dc.date.accessioned | 2019-01-29T17:51:01Z | |
dc.date.available | 2019-01-29T17:51:01Z | |
dc.date.created | 2019-01-29T17:51:01Z | |
dc.date.issued | 2002 | |
dc.identifier | Journal of Clinical Endocrinology and Metabolism, Volumen 87, Issue 1, 2018, Pages 84-89 | |
dc.identifier | 0021972X | |
dc.identifier | 10.1210/jcem.87.1.8148 | |
dc.identifier | https://repositorio.uchile.cl/handle/2250/163482 | |
dc.description.abstract | The aim of the present study was to assess the impact of treatment with GH with or without LHRH analog (LHRH-A) on bone mineralization of GH-deficient adolescents. We studied 17 pubertal, treatment-naive, GH-deficient patients (10 girls and 7 boys) in a prospective, randomized trial. Mean chronological age and mean bone age were 14.1 ± 0.4 and 11.3 ± 0.3 yr, respectively, at the beginning of the study. Treatment with GH + LHRH-A (n = 7) or GH alone (n = 10) started simultaneously. Nutropin was administered at a dose of 0.1 U/kg per day sc until patients reached near final height (NFH), defined as a bone age of 14 yr in girls and 16 yr in boys. Mean time of GH therapy in the patients treated with GH + LHRH-A was 4.8 ± 0.5 yr and in the patients treated with GH alone 2.9 ± 0.7 yr. Lupron was administered at a dose of 300 μg/kg every 28 d im for 3 yr. Bone mineral density (BMD) was assessed yearly by dual-energy x-ray absorptiometry at the lumbar spine (L2-L4) and femoral neck at the begi | |
dc.language | en | |
dc.publisher | Endocrine Society | |
dc.rights | http://creativecommons.org/licenses/by-nc-nd/3.0/cl/ | |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Chile | |
dc.source | Journal of Clinical Endocrinology and Metabolism | |
dc.subject | Endocrinology, Diabetes and Metabolism | |
dc.subject | Biochemistry | |
dc.subject | Endocrinology | |
dc.subject | Clinical Biochemistry | |
dc.subject | Biochemistry (medical) | |
dc.title | Effects of treatment with GH alone or in combination with LHRH analog on bone mineral density in pubertal GH-deficient patients | |
dc.type | Artículos de revistas | |