dc.creator | Domenech Lira, Raúl | |
dc.creator | Macho Fisher, Pilar | |
dc.creator | Vélez, Diego | |
dc.creator | Sánchez, Gina | |
dc.creator | Liu, Xueliang | |
dc.creator | Dhalla, Naranjan | |
dc.date.accessioned | 2019-01-29T17:16:07Z | |
dc.date.available | 2019-01-29T17:16:07Z | |
dc.date.created | 2019-01-29T17:16:07Z | |
dc.date.issued | 1998 | |
dc.identifier | Circulation, Volumen 97, Issue 8, 2018, Pages 786-794 | |
dc.identifier | 00097322 | |
dc.identifier | 10.1161/01.CIR.97.8.786 | |
dc.identifier | https://repositorio.uchile.cl/handle/2250/163409 | |
dc.description.abstract | Background - Myocardial ischemic preconditioning is a well-known phenomenon, however there is scant information in regard to nonischemic preconditioning. Methods and Results - We studied in anesthetized dogs the preconditioning effect of tachycardia and the mediation of adenosine and protein kinase C in this process. In a control group the anterior descending coronary artery was occluded for 60 minutes and reperfused for 270 minutes. Heart rate was kept constant at 120 ± 5 cycles/min and aortic pressure changes were damped. The infarct size (necrotic volume/risk region volume x 100) was 15.8 ± 1.5%. In another group of dogs a similar protocol was followed, but five periods of tachycardia (213 ± 12 cycles/min), 5 minutes in duration each, with 5 minutes of intervening periods at control heart rate, were induced previous to the coronary occlusion. The infarct size was reduced by 46% (P<.001) with respect to the nonpreconditioned group. This effect was not due to changes in collateral flo | |
dc.language | en | |
dc.publisher | Lippincott Williams and Wilkins | |
dc.rights | http://creativecommons.org/licenses/by-nc-nd/3.0/cl/ | |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Chile | |
dc.source | Circulation | |
dc.subject | Adenosine | |
dc.subject | Myocardial infarction | |
dc.subject | Preconditioning | |
dc.subject | Protein kinase C | |
dc.title | Tachycardia preconditions infarct size in dogs: Role of adenosine and protein kinase C | |
dc.type | Artículos de revistas | |