dc.creatorDomenech Lira, Raúl
dc.creatorMacho Fisher, Pilar
dc.creatorVélez, Diego
dc.creatorSánchez, Gina
dc.creatorLiu, Xueliang
dc.creatorDhalla, Naranjan
dc.date.accessioned2019-01-29T17:16:07Z
dc.date.available2019-01-29T17:16:07Z
dc.date.created2019-01-29T17:16:07Z
dc.date.issued1998
dc.identifierCirculation, Volumen 97, Issue 8, 2018, Pages 786-794
dc.identifier00097322
dc.identifier10.1161/01.CIR.97.8.786
dc.identifierhttps://repositorio.uchile.cl/handle/2250/163409
dc.description.abstractBackground - Myocardial ischemic preconditioning is a well-known phenomenon, however there is scant information in regard to nonischemic preconditioning. Methods and Results - We studied in anesthetized dogs the preconditioning effect of tachycardia and the mediation of adenosine and protein kinase C in this process. In a control group the anterior descending coronary artery was occluded for 60 minutes and reperfused for 270 minutes. Heart rate was kept constant at 120 ± 5 cycles/min and aortic pressure changes were damped. The infarct size (necrotic volume/risk region volume x 100) was 15.8 ± 1.5%. In another group of dogs a similar protocol was followed, but five periods of tachycardia (213 ± 12 cycles/min), 5 minutes in duration each, with 5 minutes of intervening periods at control heart rate, were induced previous to the coronary occlusion. The infarct size was reduced by 46% (P<.001) with respect to the nonpreconditioned group. This effect was not due to changes in collateral flo
dc.languageen
dc.publisherLippincott Williams and Wilkins
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
dc.sourceCirculation
dc.subjectAdenosine
dc.subjectMyocardial infarction
dc.subjectPreconditioning
dc.subjectProtein kinase C
dc.titleTachycardia preconditions infarct size in dogs: Role of adenosine and protein kinase C
dc.typeArtículos de revistas


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