Plasma concentrations of disulfiram after injection of suspended micropellets into alcoholic subjects

dc.creatorCid, Edison
dc.creatorCid, Edison
dc.creatorFeuerhake, Oscar
dc.creatorBoisier, Iris
dc.creatorChandía, Rolando
dc.date.accessioned2019-01-29T15:47:30Z
dc.date.available2019-01-29T15:47:30Z
dc.date.created2019-01-29T15:47:30Z
dc.date.issued1991
dc.identifierBiopharmaceutics & Drug Disposition, Volumen 12, Issue 2, 2018, Pages 163-169
dc.identifier1099081X
dc.identifier01422782
dc.identifier10.1002/bdd.2510120209
dc.identifierhttps://repositorio.uchile.cl/handle/2250/162383
dc.description.abstractThe disposition of disulfiram after administration in a new formulation was studied in rats and alcoholic patients. The suspension consisted of microcrystals suspended in a mixture of propylene glycol and water and injected subcutaneously into rats and humans; the course of the plasma concentration of diethyldithiocarbamate with time was followed by gas–liquid chromatography. Systemic delivery of disulfiram was observed to occur for a month. The data demonstrate that this form has the properties of a sustained‐release formulation when implanted subcutaneously. There was no evidence of local or systemic adverse reactions. Copyright © 1991 John Wiley & Sons, Ltd.
dc.languageen
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
dc.sourceBiopharmaceutics & Drug Disposition
dc.subjectAlcoholism treatment
dc.subjectDisposition
dc.subjectDisulfiram
dc.subjectImplants
dc.subjectPlasma concentrations
dc.subjectSustained‐release formulation
dc.titlePlasma concentrations of disulfiram after injection of suspended micropellets into alcoholic subjects
dc.typeArtículo de revista


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