Artículos de revistas
Human lactational response to oral thyrotropin releasing hormone
Fecha
1976Registro en:
Journal of Clinical Endocrinology and Metabolism, Volumen 43, Issue 4, 2018, Pages 760-768
19457197
0021972X
10.1210/jcem-43-4-760
Autor
Tyson, J. E.
Perez, A.
Zanartu, J.
Institución
Resumen
Several studies were designed to evaluate the effect of oral TRH on prolactin (PRL) secretion and mammary function in nursing women. Initially, efficacy was studied in nursing women following 5 mg TRH. PRL levels rose to a mean maximum of 46.3 ng/ml above baseline at 60 min. Plasma TSH also increased from a mean baseline of 2.6 to 17.6 /µU/ml at 180 min. No changes were observed following placebo. In order to observe the long term effects of oral TRH, two groups of women in full nursing were studied. Beginning on day 29 postpartum, either 5 mg TRH or placebo were taken twice daily for four weeks. No chronic elevations were observed in maternal PRL and TSH or in infant TSH before or after one month of either regimen. Milk composition expressed in terms of per cent protein and per cent fat did not differ between the groups. Weekly gonadotropin levels were also similar as were infant weight gain and growth. In a group of women with lactational insufficiency receiving 5-20 mg TRH twice dai