Effect of harmaline on pacemaker activity of guinea pig sinus node

dc.creatorCarpentier, Robert
dc.creatorNarvarte, Javier
dc.creatorSanhueza, Sylvia
dc.date.accessioned2019-01-29T15:45:57Z
dc.date.available2019-01-29T15:45:57Z
dc.date.created2019-01-29T15:45:57Z
dc.date.issued1977
dc.identifierEuropean Journal of Pharmacology, Volumen 42, Issue 4, 2018, Pages 387-390
dc.identifier00142999
dc.identifier10.1016/0014-2999(77)90173-X
dc.identifierhttps://repositorio.uchile.cl/handle/2250/162285
dc.description.abstractTransmembrane potentials of pacemaker fibers of the sinus node were recorded to analyze the effect of harmaline (HME) on cardiac automaticity. A short exposure to HME 2.1 × 10-5 or 8.3 × 10-5 M produced a long lasting non-cholinergic depression of the automaticity: the slope of diastolic depolarization of the pacemaker fibers was depressed, but the maximum diastolic potential remained unmodified. The automaticity of the sinus node was not abolished by prolonged exposure to HME 8.3 × 10-4 M, but a reversible sino-atrial block developed. © 1977.
dc.languageen
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
dc.sourceEuropean Journal of Pharmacology
dc.subjectCardiac automaticity
dc.subjectHarmaline
dc.subjectSinoatrial conduction
dc.subjectSinoatrial pacemaker
dc.titleEffect of harmaline on pacemaker activity of guinea pig sinus node
dc.typeArtículo de revista


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