| dc.creator | Ugarte, | |
| dc.creator | Pino, | |
| dc.creator | Pereda, | |
| dc.creator | Iturriaga, | |
| dc.date.accessioned | 2019-01-29T15:43:53Z | |
| dc.date.available | 2019-01-29T15:43:53Z | |
| dc.date.created | 2019-01-29T15:43:53Z | |
| dc.date.issued | 1973 | |
| dc.identifier | Pharmacology, Volumen 9, Issue 5, 2018, Pages 275-280 | |
| dc.identifier | 00317012 | |
| dc.identifier | 10.1159/000136396 | |
| dc.identifier | https://repositorio.uchile.cl/handle/2250/162225 | |
| dc.description.abstract | The effect of chronic halothane inhalation and blood ethanol elimination was studied in the rat. Hepatic α glycerophosphate, oxidase ADH and malic enzyme activities were determined. Malic enzyme activity was also assayed in adipose tissue. Halothane treated rats showed an increased ethanol elimination (378 ± 13 vs. 292 ± 19; p<0.01). Hepatic and adipose tissue malic enzyme activities were significantly enhanced in halothane treated rats (6.26 ± 1.2 vs. 1.03 ± 0.23; p<0.002 for the liver and 1.84 ± 0.71 vs. 0.75 ± 0.33 for adipose tissue). Mitochondrial α glycerophosphate oxidase activity was also significantly increased in the liver of halothane treated animals (p<0.05) while no changes in ADH activity were observed. The enhanced ethanol elimination after halothane treatment, a substance which inhibits microsomal enzyme, is possibly due to increased NADH reoxidation. Another possibility explaining augmented ethanol metabolism may be an increased incorporation of ethanol into lipids rel | |
| dc.language | en | |
| dc.rights | http://creativecommons.org/licenses/by-nc-nd/3.0/cl/ | |
| dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Chile | |
| dc.source | Pharmacology | |
| dc.subject | Pharmacology | |
| dc.title | Increased blood ethanol elimination in rats treated with halothane | |
| dc.type | Artículo de revista | |
