dc.creator | Sonoda, S. | |
dc.creator | Li, H. C. | |
dc.creator | Cartier Rovirosa, Luis | |
dc.creator | Núñez, L. | |
dc.creator | Tajima, K. | |
dc.date.accessioned | 2019-01-29T15:32:21Z | |
dc.date.available | 2019-01-29T15:32:21Z | |
dc.date.created | 2019-01-29T15:32:21Z | |
dc.date.issued | 2000 | |
dc.identifier | AIDS Research and Human Retroviruses, Volumen 16, Issue 16, 2018, Pages 1753-1756 | |
dc.identifier | 08892229 | |
dc.identifier | 10.1089/08892220050193263 | |
dc.identifier | https://repositorio.uchile.cl/handle/2250/161630 | |
dc.description.abstract | The worldwide geographic and ethnic clustering of patients with diseases related to human T cell lymphotropic virus type 1 (HTLV-1) may be explained by the natural history of HTLV-1 infection. The genetic characteristics of indigenous people in the Andes are similar to those of the Japanese, and HTLV-1 is generally detected in both groups. To clarify the common origin of HTLV-1 in Asia and the Andes, we analyzed HTLV-1 provirus DNA from Andean mummies about 1500 years old. Two of 104 mummy bone marrow specimens yielded a band of human β-globin gene DNA 110 base pairs in length, and one of these two produced bands of HTLV-1-pX (open reading frame encoding p(40x), p(27x)) and HTLV-1-LTR (long terminal repeat) gene DNA 159 base pairs and 157 base pairs in length, respectively. The nucleotide sequences of ancient HTLV-1-pX and HTLV-1-LTR clones isolated from mummy bone marrow were similar to those in contemporary Andeans and Japanese, although there was microheterogeneity in the sequences | |
dc.language | en | |
dc.rights | http://creativecommons.org/licenses/by-nc-nd/3.0/cl/ | |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Chile | |
dc.source | AIDS Research and Human Retroviruses | |
dc.subject | Immunology | |
dc.subject | Virology | |
dc.subject | Infectious Diseases | |
dc.title | Ancient HTLV type 1 provirus DNA of andean mummy | |
dc.type | Artículo de revista | |