dc.creator | Giraudon, Pascale | |
dc.creator | Szymocha, Raphaël | |
dc.creator | Buart, Stéphanie | |
dc.creator | Bernard, Arlette | |
dc.creator | Cartier Rovirosa, Luis | |
dc.creator | Belin, Marie Françoise | |
dc.creator | Akaoka, Hideo | |
dc.date.accessioned | 2019-01-29T15:32:21Z | |
dc.date.available | 2019-01-29T15:32:21Z | |
dc.date.created | 2019-01-29T15:32:21Z | |
dc.date.issued | 2000 | |
dc.identifier | Journal of Immunology, Volumen 164, Issue 5, 2018, Pages 2718-2727 | |
dc.identifier | 00221767 | |
dc.identifier | 10.4049/jimmunol.164.5.2718 | |
dc.identifier | https://repositorio.uchile.cl/handle/2250/161626 | |
dc.description.abstract | Activation of T lymphocytes by human pathogens is a key step in the development of immune-mediated neurologic diseases. Because of their ability to invade the CNS and their increased secretion of proinflammatory cytokines, activated CD4+ T cells are thought to play a crucial role in pathogenesis. In the present study, we examined the expression of inflammatory mediators the cytokine-induced metalloproteinases (MMP-2, -3, and -9) and their endogenous inhibitors, tissue inhibitors of metalloproteinases (TIMP-1, -2, and -3), in human astrocytes in response to activated T cells. We used a model system of CD4+ T lymphocytes activated by persistent viral infection (human T lymphotropic virus, HTLV-I) in transient contact with human astrocytes. Interaction with T cells resulted in increased production of MMP- 3 and active MMP-9 in astrocytes despite increased expression of endogenous inhibitors, TIMP-1 and TIMP-3. These data suggest perturbation of the MMP/TIMP balance. These changes in MMP a | |
dc.language | en | |
dc.publisher | American Association of Immunologists | |
dc.rights | http://creativecommons.org/licenses/by-nc-nd/3.0/cl/ | |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Chile | |
dc.source | Journal of Immunology | |
dc.subject | Immunology and Allergy | |
dc.subject | Immunology | |
dc.title | T lymphocytes activated by persistent viral infection differentially modify the expression of metalloproteinases and their endogenous inhibitors, TIMPs, in human astrocytes: Relevance to HTLV-I-induced neurological disease | |
dc.type | Artículos de revistas | |