dc.creatorBull Simpfendorfer, Ricardo
dc.creatorMarengo, Juan José
dc.date.accessioned2019-01-29T14:52:55Z
dc.date.available2019-01-29T14:52:55Z
dc.date.created2019-01-29T14:52:55Z
dc.date.issued1993
dc.identifierFEBS Letters, Volumen 331, Issue 3, 2018, Pages 223-227
dc.identifier00145793
dc.identifier10.1016/0014-5793(93)80341-Q
dc.identifierhttps://repositorio.uchile.cl/handle/2250/161126
dc.description.abstractCalcium channels derived from sarcoplasmic reticulum of frog skeletal muscle were fused with planar lipid bilayers. Fractional open times displayed two types of calcium dependence: (i) blockable channels showed a bell-shaped calcium dependence with an activation constant of 4.5 μM, a Hill coefficient for activation of 1.46 and a blocking constant of 226 μM, and (ii) non-blockable channels displayed a sigmoidal calcium dependence with an activation constant of 1.1 μM and a Hill coefficient of 1.42; no blocking effect was seen with calcium up to 0.5 mM. These two types of calcium dependence may underlie the coexistence of two different pathways for calcium release in frog skeletal muscle. © 1993.
dc.languageen
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
dc.sourceFEBS Letters
dc.subjectCa2+channel
dc.subjectCa2+regulation
dc.subjectCa2+release
dc.subjectSarcoplasmic reticulum
dc.subjectSkeletal muscle
dc.titleSarcoplasmic reticulum release channels from frog skeletal muscle display two types of calcium dependence
dc.typeArtículo de revista


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