Artículo de revista
Cardiorespiratory reflex due to pulmonary J receptors stimulation by acetaldehyde in rats
Fecha
1992Registro en:
Alcohol, Volumen 9, Issue 4, 2018, Pages 317-322
07418329
10.1016/0741-8329(92)90073-J
Autor
Brugère, Solange S.
Penna Varela, Mario
Corrales, Raul J.
Institución
Resumen
Acetaldehyde (AcH) administered intravenously or into the right ventricle induces reflex bradycardia, hypotension, and apnea in the rat. The efferent pathway for this reflex is vagal and probably secondary to pulmonary J receptors stimulation. Located between the alveoli and the pulmonary capillary, J receptors are accessible through the pulmonary circulation and the airways. For this reason, a method for indirect nebulization (IN) of AcH into the airways, that provides a continuous record of respiration without changes in intrapulmonary pressure, was developed. IN of AcH (n = 14) induced bradycardia (64 ± 3.1%), hypotension (34 ± 4.2%), and apnea (79%), which were blocked by vagotomy (n = 9). The latencies (s) for bradycardia (0.34 ± 0.06), hypotension (0.68 ± 0.11), and apnea (0.25 ± 0.11) were significantly shorter than those obtained by the intravenous route. Three rats that did not develop apnea had an equivalent response, where both tidal volume and minute ventilation decreased a