Artículos de revistas
Ovarian steroidal response to gonadotropins and β-Adrenergic stimulation is enhanced in polycystic ovary syndrome: Role of sympathetic innervation
Fecha
1993Registro en:
Endocrinology, Volumen 133, Issue 6, 2018, Pages 2696-2703
19457170
00137227
10.1210/endo.133.6.8243293
Autor
Barria, A.
Leyton, V.
Ojeda, S. R.
Lara Peñaloza, Hernán
Institución
Resumen
Experimental induction of a polycystic ovarian syndrome (PCOS) in rodents by the administration of a single dose of estradiol valerate (EV) results in activation of the peripheral sympathetic neurons that innervate the ovary. This activation is evidenced by an increased capacity of ovarian nerve terminals to incorporate and release norepinephrine (NE), an increase in ovarian NE content, and a decrease in ovarianβ-adrenergic receptor number in the ovarian compartments receiving catecholaminergic innervation. The present experiments were undertaken to examine the functional consequences of this enhanced sympathetic outflow to the ovary. The steroidal responses of the gland toβ-adrenergic receptor stimulation and hCG were examined in vitro 60 days after EV administration, i.e. at the time when follicular cysts are well established. EV-treated rats exhibited a remarkable increase in ovarian progesterone and androgen responses to isoproterenol, aβ-adrenergic receptor agonist, with no change