dc.creator | Lackington, Inés | |
dc.creator | Orrego, Fernando | |
dc.date.accessioned | 2019-01-29T14:47:16Z | |
dc.date.available | 2019-01-29T14:47:16Z | |
dc.date.created | 2019-01-29T14:47:16Z | |
dc.date.issued | 1986 | |
dc.identifier | Brain Research, Volumen 378, Issue 2, 2018, Pages 390-393 | |
dc.identifier | 00068993 | |
dc.identifier | 10.1016/0006-8993(86)90943-1 | |
dc.identifier | https://repositorio.uchile.cl/handle/2250/160599 | |
dc.description.abstract | Net K fluxes in in vitro suspensions of sliced rat brain cortex were studied by means of a K-sensitive electrode. When incubation was in 3 mM K, a net K efflux occurred. It could be resolved into two first-order rate constants: k1=0.486 min-1, and k2=0.0102 min-1, that originated from compartments that contained 18% and 82% of tissue K, respectively. k1 Was suppressed by tetrodotoxin (TTX), and k2 was increased 38-fold by veratridine. The latter effect was blocked by TTX, methylphenidate (1 mM), creatine (25 mM), apamin (50 nM), quinine (100 μM), verapamil (22 μM) or D-600 (38 μM). Net K loss was greatly increased by 1 mM ouabain, and enhanced by sodium azide plus iodoacetamide, but not by 0.1 M ethanol. Glutamate (5 mM) induced a considerable and rapid net uptake of K, while aspartate or N-methylaspartate increased K efflux. © 1986. | |
dc.language | en | |
dc.rights | http://creativecommons.org/licenses/by-nc-nd/3.0/cl/ | |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Chile | |
dc.source | Brain Research | |
dc.subject | apamin | |
dc.subject | brain cortex | |
dc.subject | creatine | |
dc.subject | glutamate | |
dc.subject | potassiu | |
dc.subject | veratridine | |
dc.title | Continuous measurement of net potassium movements in rat brain cortex suspensions. Effects of glutamate, veratridine, creatine and other substances | |
dc.type | Artículo de revista | |