dc.creator | Silva, J. Enrique | |
dc.creator | Santelices, Raül | |
dc.creator | Kishihara, Michizo | |
dc.creator | Schneider, Arthur | |
dc.date.accessioned | 2019-01-29T14:47:05Z | |
dc.date.available | 2019-01-29T14:47:05Z | |
dc.date.created | 2019-01-29T14:47:05Z | |
dc.date.issued | 1984 | |
dc.identifier | Journal of Clinical Endocrinology and Metabolism, Volumen 58, Issue 3, 2018, Pages 526-534 | |
dc.identifier | 19457197 | |
dc.identifier | 0021972X | |
dc.identifier | 10.1210/jcem-58-3-526 | |
dc.identifier | https://repositorio.uchile.cl/handle/2250/160536 | |
dc.description.abstract | We characterized the abnormal thyroglobulin (TG) in the thyroid and serum of a 12-yr-old girl with a large sporadic multinodular goiter first noted at age 4 yr. She developed normallyand had no clinical evidence of hypothyroidism. However, her serum T4 was less than 1.0/µg/dl, T3 was 125 ng/ dl, and TSH was 155 µU/ml. Serum PBI was 9.7 /µg/dl, and more than 90% was not extractable with butanol. The 24-h radioactive iodine uptake was 55%, not dischargeable by perchlorate. Hormone formation was tested by the administration of 131I before surgery. [131I]T4 and [131I]T3) but not 131I-labeled iodotyrosines, were present in the thyroidal venous blood. Hydrolysis of 10,000 × g supernatants from three randomly obtained samples of the goiter revealed 66–77% of the 131I asiodotyrosines, 2–4% as iodothyronines, and 10–12% as undigestable material; the MIT to DIT ratio ranged from 3.1–8.7, and the T4 to T3 ratio rangedfrom 2.3–8.3. The TG level was 2.5 mg/g in the goiter and 9.4 /µg/ml in the seru | |
dc.language | en | |
dc.rights | http://creativecommons.org/licenses/by-nc-nd/3.0/cl/ | |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Chile | |
dc.source | Journal of Clinical Endocrinology and Metabolism | |
dc.subject | Endocrinology, Diabetes and Metabolism | |
dc.subject | Biochemistry | |
dc.subject | Endocrinology | |
dc.subject | Clinical Biochemistry | |
dc.subject | Biochemistry (medical) | |
dc.title | Low molecular weight thyroglobulin leading to a goiter in a 12-year-old girl | |
dc.type | Artículo de revista | |