dc.creator | Oyarzún, Manuel J. | |
dc.creator | Donoso Laurent, Paulina | |
dc.creator | Arias, Mónica | |
dc.creator | Quijada, Dolly | |
dc.date.accessioned | 2019-01-29T14:47:02Z | |
dc.date.available | 2019-01-29T14:47:02Z | |
dc.date.created | 2019-01-29T14:47:02Z | |
dc.date.issued | 1984 | |
dc.identifier | Respiration, Volumen 46, Issue 2, 2018, Pages 231-240 | |
dc.identifier | 14230356 | |
dc.identifier | 00257931 | |
dc.identifier | 10.1159/000194694 | |
dc.identifier | http://repositorio.uchile.cl/handle/2250/160523 | |
dc.description.abstract | Intravenous infusion of free fatty acid (FFA) produces pulmonary edema and an increase in the alveolar surfactant content of the rabbit. In order to identify a likely mediator of this lung response to FFA, we used inhibitors of cyclo-oxygenase (indomethacin, 15 mg.kg<sup>-1</sup> i.v., or meclofenamate, 5 mg.kg<sup>-1</sup> i.v.) and thromboxane syn-thetase inhibitors (imidazole, 50 mg.kg<sup>-1</sup> i.v. or dazoxiben, 2 mg.kg<sup>-1</sup> i.v.) which were administered before FFA, 20 mg. kg<sup>-1</sup> min<sup>-1</sup> i.v., in four different experimental series (n = 54). Lung surfactant was measured in bronchial-alveolar lavage fluid by determining disaturated phosphatidylcholine (DSPC). Both kinds of inhibitors blocked the increase in FFA-induced DSPC. They increased the survival rate but they only slightly changed the post-FFA morphofunctional pulmonary alterations. We conclude that the increase in alveolar surfactant induced by FFA is likely mediated by thromboxane. This mediator | |
dc.language | en | |
dc.rights | http://creativecommons.org/licenses/by-nc-nd/3.0/cl/ | |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Chile | |
dc.source | Respiration | |
dc.subject | Alveolar surfactant | |
dc.subject | Dazoxiben | |
dc.subject | Disaturated phosphatidylcholine | |
dc.subject | Free fatty acids | |
dc.subject | Imidazole | |
dc.subject | Indomethacin | |
dc.subject | Meclofenamate | |
dc.subject | Pulmonary edema | |
dc.subject | Respiratory failure | |
dc.subject | Thromboxane | |
dc.title | Thromboxane mediates the increase in alveolar surfactant pool induced by free fatty acid infusion in the rabbit | |
dc.type | Artículos de revistas | |