Artículo de revista
Hyperprolactinemia and galactorrhea: Spontaneous versus iatrogenic hypothyroidism
Fecha
1981Registro en:
Journal of Clinical Endocrinology and Metabolism, Volumen 53, Issue 5, 2018, Pages 1036-1039
19457197
0021972X
10.1210/jcem-53-5-1036
Autor
Serrano Contreras, Patricio
Generini, Gladys
Michelsen, Harold
Pumarino, Hugo
Campino, Carmen
Institución
Resumen
Although hyperprolactinemia and galactorrhea occur in primary hypothyroidism, factors influencing their presence are not well established. To further define these factors, the duration of illness and serum levels of PRL and TSH were investigated in a group of 50 patients with spontaneous (27 females and 7 males) and iatrogenic (16 females) primary hypothyroidism. To test the hypothesis of reduced hypothalamic dopamine content in overt long-standing primary hypothyroidism, the percent increase in serum PRL after the administration of metoclopramide, a dopamine blocker (2.5 mg, iv bolus), was studied in 13 women with spontaneous primary hypothyroidism and compared with that in 10 euthyroid women. While 88.2% of the patients with spontaneous primary hypothyroidism were hyperprolactinemic, only 31% of those with iatrogenic disease had elevated PRL levels. Women with spontaneous primary hypothyroidism had a longer duration of illness (72 ± 12 vs. 6.7 ± 1.8 months; P < 0.001) and higher seru