Artículo de revista
Resultados del tratamiento de la hepatitis crónica por virus C en un hospital público, en Chile
Fecha
2012Registro en:
Revista Medica de Chile, Volumen 140, Issue 12, 2012, Pages 1529-1534
00349887
07176163
10.4067/S0034-98872012001200002
Autor
Aravena, Edmundo
Pinto, Andrea
Roblero Cum, Juan
González, Marcela Z.
Iturriaga, Hernán
Institución
Resumen
Background: Chronic hepatitis C is an important health problem in Chile. In
2005, the Ministry of Health started a pilot treatment program with peg interferon
and ribavirin, to be developed in public hospitals all over the country. Aim: To report
the results of hepatitis C treatment obtained at our institution. Patients and Methods: Between 2005 and 2009, 63 patients were referred for treatment. In all, the
viral load and genotype were determined. Peg interferon alpha-2a or alpha-2b plus
ribavirin were used for therapy for up to 48 weeks in genotypes (G) 1 or 4 or 24 weeks
in genotypes 2 or 3. If at the end of treatment, viral load measured by polymerase
chain reaction (PCR) was negative, it was repeated 6 months later. A negative viral
load at that time was considered a sustained viral response (SVR). Results: Among
the 51 patients who started treatment, 42 (80.4%) were G1, 1 was G2, 1 was G4 and
7 were G3. A SVR was reached in 51.1% of G 1 and 4 and in 87.5% in G 3 and 2.
In a univariate analysis, the variables significantly associated with a positive viral
response were the degree of fibrosis and body mass index. Conclusions: These results
are similar to those obtained in other international series, demonstrating that Hispanic ethnicity does not influence the response to treatment. Our good results could
be explained by the excellent compliance of the patients to the treatment. A higher
degree of fibrosis and a higher BMI were associated with a poor response.