dc.creator | Gutiérrez, Tomás | |
dc.creator | Parra, Valentina | |
dc.creator | Troncoso, Rodrigo | |
dc.creator | Pennanen, Christian | |
dc.creator | Contreras Ferrat, Ariel Eduardo | |
dc.creator | Vásquez Trincado, César Alonso | |
dc.creator | Morales, Pablo E. | |
dc.creator | López Crisosto, Camila | |
dc.creator | Sotomayor Flores, Cristian Alejandro | |
dc.creator | Chiong Lay, Mario | |
dc.creator | Rothermel, Beverly A. | |
dc.creator | Lavandero González, Sergio | |
dc.date.accessioned | 2018-12-20T15:13:15Z | |
dc.date.available | 2018-12-20T15:13:15Z | |
dc.date.created | 2018-12-20T15:13:15Z | |
dc.date.issued | 2014 | |
dc.identifier | Cell Communication and Signaling, Volumen 12, Issue 1, 2018, | |
dc.identifier | 1478811X | |
dc.identifier | 10.1186/s12964-014-0068-4 | |
dc.identifier | https://repositorio.uchile.cl/handle/2250/158560 | |
dc.description.abstract | © 2014 Gutierrez et al.; licensee BioMed Central Ltd. Background: Cardiac hypertrophy is characterized by alterations in both cardiac bioenergetics and insulin sensitivity. Insulin promotes glucose uptake by cardiomyocytes and its use as a substrate for glycolysis and mitochondrial oxidation in order to maintain the high cardiac energy demands. Insulin stimulates Ca2+ release from the endoplasmic reticulum, however, how this translates to changes in mitochondrial metabolism in either healthy or hypertrophic cardiomyocytes is not fully understood. Results: In the present study we investigated insulin-dependent mitochondrial Ca2+ signaling in normal and norepinephrine or insulin like growth factor-1-induced hypertrophic cardiomyocytes. Using mitochondrion-selective Ca2+-fluorescent probes we showed that insulin increases mitochondrial Ca2+ levels. This signal was inhibited by the pharmacological blockade of either the inositol 1,4,5-triphosphate receptor or the mitochondrial Ca2+ uniport | |
dc.language | en | |
dc.publisher | BioMed Central Ltd. | |
dc.rights | http://creativecommons.org/licenses/by-nc-nd/3.0/cl/ | |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Chile | |
dc.source | Cell Communication and Signaling | |
dc.subject | Akt | |
dc.subject | Calcium | |
dc.subject | Cardiac hypertrophy | |
dc.subject | Catecholamines | |
dc.subject | IGF-1 | |
dc.subject | Inositol 1,4,5-triphosphate receptor | |
dc.subject | Insulin | |
dc.subject | Mitochondria | |
dc.title | Alteration in mitochondrial Ca2+ uptake disrupts insulin signaling in hypertrophic cardiomyocytes | |
dc.type | Artículos de revistas | |