dc.creator | Fritz, Hans | |
dc.creator | Ortiz, Andrea | |
dc.creator | Velaga, Sitaram | |
dc.creator | Morales, Javier | |
dc.date.accessioned | 2018-12-20T15:11:48Z | |
dc.date.available | 2018-12-20T15:11:48Z | |
dc.date.created | 2018-12-20T15:11:48Z | |
dc.date.issued | 2018 | |
dc.identifier | Drug Delivery and Translational Research, Volumen 8, Issue 6, 2018, Pages 1807-1814 | |
dc.identifier | 21903948 | |
dc.identifier | 2190393X | |
dc.identifier | 10.1007/s13346-018-0521-9 | |
dc.identifier | https://repositorio.uchile.cl/handle/2250/158459 | |
dc.description.abstract | High-energy methods for the manufacturing of nanomedicines are widely used; however, interest in low-energy methods is increasing due to their simplicity, better control over the process, and energy-saving characteristics during upscaling. Here, we developed a novel lipid-core micelle (LCM) as a nanocarrier to encapsulate a poorly water-soluble drug, nifedipine (NFD), by hot-melt emulsification, a low-energy method. LCMs are self-assembling colloidal particles composed of a hydrophobic core and a hydrophilic shell. Hybrid materials, such as Gelucire 44/14, are thus excellent candidates for their preparation. We characterized the obtained nanocarriers for their colloidal properties, drug loading and encapsulation efficiency, liquid state, stability, and drug release. The low-energy method hot-melt emulsification was successfully adapted for the manufacturing of small and narrowly dispersed LCMs. The obtained LCMs had a small average size of ~ 11 nm and a narrow polydispersity index (PDI) of 0.228. These nanocarriers were able to increase the amount of NFD dispersible in water more than 700-fold. Due to their sustained drug release profile and the PEGylation of Gelucire 44/14, these nanocarriers represent an excellent starting point for the development of drug delivery systems designed for long circulation times and passive targeting. | |
dc.language | en | |
dc.publisher | Springer Verlag | |
dc.rights | http://creativecommons.org/licenses/by-nc-nd/3.0/cl/ | |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Chile | |
dc.source | Drug Delivery and Translational Research | |
dc.subject | Hot-melt emulsification | |
dc.subject | Lipid-core micelles | |
dc.subject | Low-energy method | |
dc.subject | Nanocarriers | |
dc.subject | Poorly water soluble drugs | |
dc.title | Preparation of a novel lipid-core micelle using a low-energy emulsification method | |
dc.type | Artículo de revista | |