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Exploring the influence of Diels–Alder linker length on photothermal molecule release from gold nanorods
Fecha
2018Registro en:
Colloids and Surfaces B: Biointerfaces, Volumen 166,
18734367
09277765
10.1016/j.colsurfb.2018.03.021
Autor
Vetterlein, Claudia
Vásquez Salfate, Rodrigo
Bolaños, Karen
Acosta, Gerardo A.
Guzman, Fanny
Albericio, Fernando
Celis, Freddy
Campos, Marcelo
Kogan Bocian, Marcelo
Araya, Eyleen
Institución
Resumen
© 2018 Elsevier B.V. We studied the photothermal release of carboxyfluorescein (CF) linked to the gold surface of gold nanorods (GNRs) by two Diels–Alder adducts of different lengths (n = 4 and n = 9). The functionalized GNRs were irradiated with infrared light to produce photothermal release of CF by a retro-Diels–Alder reaction. The adducts were chemisorbed on the GNRs and the functionalized nanoparticles were characterized by UV–vis, DLS, zeta potential and Raman and surface-enhanced Raman spectroscopy (SERS). On the basis of the degree of nanoparticle functionalization and the SERS results, we inferred the orientation of CF on the surface of the gold nanoparticle. Moreover, we determined the photothermal release profiles of CF from the gold surface by laser irradiation. The release was faster for the longer linker (n = 9). SERS revealed that, for the shorter linker (n = 4), molecules are oriented perpendicularly with respect to the gold surface, thereby maintaining the CF far from