dc.creator | Leal, D. | |
dc.creator | Mansilla, A. | |
dc.creator | Matsuhiro, B. | |
dc.creator | Moncada-Basualto, Mauricio | |
dc.creator | Lapier, M. | |
dc.creator | Maya Arango, Juan | |
dc.creator | Olea Azar, Claudio | |
dc.creator | De Borggraeve, W. M. | |
dc.date.accessioned | 2018-12-20T15:11:41Z | |
dc.date.available | 2018-12-20T15:11:41Z | |
dc.date.created | 2018-12-20T15:11:41Z | |
dc.date.issued | 2018 | |
dc.identifier | Carbohydrate Polymers, Volumen 199, | |
dc.identifier | 01448617 | |
dc.identifier | 10.1016/j.carbpol.2018.07.012 | |
dc.identifier | https://repositorio.uchile.cl/handle/2250/158423 | |
dc.description.abstract | © 2018 Elsevier Ltd This work is related to the structural characterization of the sulfated polysaccharide from Lessonia sp and the study of its antioxidant and antiparasitic properties. Sequential extraction afforded D-mannitol as the only low MW sugar alcohol. Extraction with 2% CaCl2 afforded in 3.0% yield, a sulfated fucan (SF). Its major fraction (48.5% yield), isolated by ion-exchange chromatography corresponds to a linear polymer of α-L-fucopyranosil residues linked 1→3, sulfated at the O–4 and partially at O–2 positions. By alkaline extraction, sodium alginate (10.3% yield) was obtained. The antioxidant capacity of SF by ESR showed high elimination index (IC50, mg/mL) of hydroxyl (0.27), alkoxy (10.05), and peroxyl (82.88) radicals in relation to commercial mannitol. SF showed activity against the epimastigote form of Trypanosoma cruzi parasite (250 μg/mL) and low cytotoxicity in murine cells (367 μg/mL). The elimination capacity of radicals in aqueous medium of SF would allow | |
dc.language | en | |
dc.publisher | Elsevier Ltd | |
dc.rights | http://creativecommons.org/licenses/by-nc-nd/3.0/cl/ | |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Chile | |
dc.source | Carbohydrate Polymers | |
dc.subject | Antioxidant | |
dc.subject | Antiparasitic | |
dc.subject | Biological activities | |
dc.subject | Fucoidan | |
dc.subject | Sulfated fucan | |
dc.title | Chemical structure and biological properties of sulfated fucan from the sequential extraction of subAntarctic Lessonia sp (Phaeophyceae) | |
dc.type | Artículos de revistas | |