dc.creatorLeal, D.
dc.creatorMansilla, A.
dc.creatorMatsuhiro, B.
dc.creatorMoncada-Basualto, Mauricio
dc.creatorLapier, M.
dc.creatorMaya Arango, Juan
dc.creatorOlea Azar, Claudio
dc.creatorDe Borggraeve, W. M.
dc.date.accessioned2018-12-20T15:11:41Z
dc.date.available2018-12-20T15:11:41Z
dc.date.created2018-12-20T15:11:41Z
dc.date.issued2018
dc.identifierCarbohydrate Polymers, Volumen 199,
dc.identifier01448617
dc.identifier10.1016/j.carbpol.2018.07.012
dc.identifierhttps://repositorio.uchile.cl/handle/2250/158423
dc.description.abstract© 2018 Elsevier Ltd This work is related to the structural characterization of the sulfated polysaccharide from Lessonia sp and the study of its antioxidant and antiparasitic properties. Sequential extraction afforded D-mannitol as the only low MW sugar alcohol. Extraction with 2% CaCl2 afforded in 3.0% yield, a sulfated fucan (SF). Its major fraction (48.5% yield), isolated by ion-exchange chromatography corresponds to a linear polymer of α-L-fucopyranosil residues linked 1→3, sulfated at the O–4 and partially at O–2 positions. By alkaline extraction, sodium alginate (10.3% yield) was obtained. The antioxidant capacity of SF by ESR showed high elimination index (IC50, mg/mL) of hydroxyl (0.27), alkoxy (10.05), and peroxyl (82.88) radicals in relation to commercial mannitol. SF showed activity against the epimastigote form of Trypanosoma cruzi parasite (250 μg/mL) and low cytotoxicity in murine cells (367 μg/mL). The elimination capacity of radicals in aqueous medium of SF would allow
dc.languageen
dc.publisherElsevier Ltd
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
dc.sourceCarbohydrate Polymers
dc.subjectAntioxidant
dc.subjectAntiparasitic
dc.subjectBiological activities
dc.subjectFucoidan
dc.subjectSulfated fucan
dc.titleChemical structure and biological properties of sulfated fucan from the sequential extraction of subAntarctic Lessonia sp (Phaeophyceae)
dc.typeArtículos de revistas


Este ítem pertenece a la siguiente institución