Artículos de revistas
NMR and molecular fluorescence spectroscopic study of the structure and thermodynamic parameters of EGCG/β-cyclodextrin inclusion complexes with potential antioxidant activity
Fecha
2014Registro en:
Journal of Inclusion Phenomena and Macrocyclic Chemistry, Volumen 78, Issue 1-4, 2018, Pages 287-298
09230750
10.1007/s10847-013-0297-y
Autor
Folch Cano, Christian
Guerrero, Juan
Speisky Cosoy, Hernán
Jullian Matthaei, Carolina
Olea Azar, Claudio
Institución
Resumen
The present study is focused on the characterization of the interaction between (-)-epigallocatechingallate (EGCG) and cyclodextrins like β-cyclodextrin (βCD), heptakis(2,6 di-O-methyl)-β-cyclodextrin (DMβCD), and hydroxypropyl-β-cyclodextrin (HPβCD) in aqueous solution. These inclusion complexes previously demonstrated improvements in the antioxidant activity respect to free EGCG. The structural evidence obtained by 2D-ROESY and selective 1D-ROESY experiments was rationalized by autodock studies and indicates that all the complexes have similar inclusion geometries, but the difference resides on the exposition degree of the antioxidant rings of EGCG, such as pyrogallol and galloyl groups. The thermodynamic study allowed estimating that the inclusion process is entalpically driven for the derivatized cyclodextrins complexes and entropically driven for βCD complexes due to the predominance of hydrophobic interactions with EGCG. © 2013 Springer Science+Business Media Dordrecht.