dc.creator | Andrés, Sergio | |
dc.creator | Cárdenas, Sergio | |
dc.creator | Lecocq Parra, Claudio | |
dc.creator | Bravo, Javier | |
dc.creator | Greiner, Monika | |
dc.creator | Rojas, Paulina | |
dc.creator | Morales, Paola | |
dc.creator | Lara Peñaloza, Hernán | |
dc.creator | Fiedler Temer, Jenny | |
dc.date.accessioned | 2018-12-20T15:10:07Z | |
dc.date.available | 2018-12-20T15:10:07Z | |
dc.date.created | 2018-12-20T15:10:07Z | |
dc.date.issued | 2006 | |
dc.identifier | Endocrine, Volumen 29, Issue 2, 2018, Pages 299-307 | |
dc.identifier | 1355008X | |
dc.identifier | 10.1385/ENDO:29:2:299 | |
dc.identifier | http://repositorio.uchile.cl/handle/2250/158149 | |
dc.description.abstract | Reduction in corticosterone by acute adrenalectomy (5 d) promotes apoptosis in dentate gyrus (DG) granular neurons, an effect concomitant with variations in the expression of the Bcl-2 gene family implicated in apoptotic regulation. However, no studies exist correlating the effect of long-term adrenalectomy (30 d) on the hippocampus in terms of extent of apoptosis and the levels of proteins related to an apoptotic cascade. After 5 d of adrenalectomy, we found an increase in apoptosis of the DG granular region, correlated with an increase in the processing of caspase-9. The magnitude of apoptosis 30 d after adrenalectomy was reduced in the DG granular layer compared with 5 d after adrenalectomy, in close relation to a reduction in the level of processed caspase-9. To understand how the increase in cell survival long after adrenalectomy occurs, we analyzed changes in the expression of genes and proteins related to apoptosis. Long-term adrenalectomy did not change hippocampal pro-apoptoti | |
dc.language | en | |
dc.rights | http://creativecommons.org/licenses/by-nc-nd/3.0/cl/ | |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Chile | |
dc.source | Endocrine | |
dc.subject | Adrenalectomy | |
dc.subject | Apoptosis | |
dc.subject | BAD | |
dc.subject | BAX | |
dc.subject | BCL-2 | |
dc.subject | BCL-XL | |
dc.subject | Corticosterone | |
dc.title | Effects of long-term adrenalectomy on apoptosis and neuroprotection in the rat hippocampus | |
dc.type | Artículos de revistas | |